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Received : 07-04-2024

Accepted : 15-05-2024



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Get Permission Basuri, Mohapatra, Dhal, and Kharat: A meta analysis study on plants used by tribes of various districts of Odisha for treatment of liver disease


Introduction

The maximum population of India lives in rural areas and forests, and they use various parts of plants as food, medicine and other daily necessities.1 The tribes of India used medicinal plants from prehistoric time, and they continue to provide useful tools for treating various aliments2 More than 50,000 out of 4,22,000 flowering plants are used for medicinal purposes.3

The studies about traditional knowledge4 from many parts of the world have shown that the selection of traditional plants in practice is driven by both cultural ad environmental factors. Ethnobotanical 5 study looks at information about the tribes6 and people living in the areas especially traditional medicines7 that are prepared from plants, food habits, traditional agricultural practices, housing, arts and crafts made outside of plant products 8 etc. In India about 65% of the total and 85% of rural people 9 rely on traditional knowledge of health care. India is one of the mega biodiversity countries I the world with rich vegetation of about 45000 artificial vegetation.10 In Odisha different types of herbal drugs are used by practitioners of different villages. Now a day herbal medicine is safetest to use in compare to allopathic drugs. In Odisha different tribes11 are found using different parts of plants as medicines for treatment of liver diseases. The tribes include Bonda, Bhuyan, Savara, Santhal, Ho, Saora, Kondha, Khadia, Juang 12 which are found in various villages and forest pockets located in Odisha.

Table 1

Plant drugs used as single plant remeides against liver diseases by the tribal pockets of various districts of Odisha

Plant name

Family

Part used

Tribe reported

Model

Extract used

Parameters

Histopathology

Acacia catechu

Fabaceae

Gum

Juang, Bathudi

Acetaminophen induced

Seed and Bark extract

AST, ALP, ALT

Narcosis, Polymorphonuclear cells infiltration and sinusoidal congestion

13

Andrographis paniculata

Acanthaceae

Whole herb

Savara, Santhal, Kondha, Paroja

CCl4 induced

Whole plant

TP, Bilirubin, creatinine, urea, serum glucose

Increase in antioxidant enzymes in liver

14

Astercantha longifola

Acanthaceae

Root, Seed

Ho, Khadia

Isoniazid and Rifampicin induced

Aerial parts

ALT, AST, SB, SAKP, TP, Total protein, albumin

hematoxylin–eosin-stained liver

15

Allium sativum

Liliaceae

Bulblet

Santhal, Kondha

Thioacetamide induced

Bulblets

ALT, AST, TOTAL BILIRUBIN

Severe hepatic damage

16

Apium graveolens

Apiaceae

Fruit

Bhumji

Paracetamol and thioacetamide induced

Seeds

SGOT, SGPT, SALP, SSDH, SGLDH, SBRN, HTG

Gross necrosis of centrilobular hepatocytes characterized by nuclear pyknosis and eosinophilic infiltration

17

Daucus carota

Apiaceae

Root

All plain tribes

CCl4 induced

Fresh tuber roots

SGOT, SGPT, LDH

stimulation of hepatic regeneration

18

Trachyspermum ammi

Apiaceae

Fruit

Bhumji

Ibuprofen induced

seeds

Percentage viability of cell line and cytotoxicity activity

liver metabolic functions and toxicity of xenobiotics

19

Azadiracta indica

Meliaceae

Stem bark

All plain tribes

CCl4 induced

Leaves

ALT and AST

mild congestion in some of the sinusoid

20

B. diffusa

Nyctaginaceae

Root, Young leaf

Bonda, Bhuyan

D-Galctosamine induced

Whole plant

AST, ALT, ALP, TP, TB, GGPT and total albumin.

analysis of oxidative stress-related biomarkers and in phosphate - buffered formalin

21

Boerhavia chinensis

Nyctaginaceae

Root

Bonda, Bhuyan

CCl4 induced

Whole plant

SGPT, SGOT, ALP and BIT

mild portal triadetis and focal semisolid congestion

22

Cassia occidentale

Caesalpiniaceae

Stem bark

Mankind

CCl4 induced

Leaves

ALT, AST, and ALP

centrilobular necrosis, ballooning degeneration and vacuolation of hepatocytes

23

Cichorium intybus

Asteraceae

Root

Practitioners

CCl4 induced

Aerial parts

ALT, AST, TB, ALP

centrilobular hepatic necrosis, fatty change, apoptotic bodies and ballooning degeneration

24

Eclipta prostrata

Asteraceae

Root

Kondha

CCl4 induced

Whole plant

AST, ALT, ALP, ACP

Necrosis and membrane damage

25

Eclipta alba

Asteraceae

Root

Kondha

CCl4 induced

Whole plant

AST, ALP, ALT, TP, Triglyceride, Cholesterol, Phospholipids

Regulates hepatic microsomal drug metabolizing enzymes

26

Wedelia chinensis

Asteraceae

Root

Mankind

CCl4 induced

Whole plant

SGOT, SGPT, SLAP

necrosis and vacuolization

27

Citrullus vulgaris

Cucurbitaceae

Seeds

Savara

CCl4 induced

roots

ALT, AST, TG, HA, LN

Necrosis, lymphocyte, infiltration and fatty degeneration

28

Embelia ribes

Myrsinaceae

Seeds

Plain and tribes

Paracetamol induced

Whole plant

ALT, AST

Hepatic necrosis

29

Odenlandia corymbosa

Rubiaceae

Root

Bonda

Anti-tubercular drug induced

Whole plant

ALT, AST, ALP, SB

Hepatic necrosis

30

Glycomis pentaphylla

Rutaceae

Leaf

Kondha

Paracetamol induced

Leaves

ALT, AST, ALT, ALP, Total bilirubin and total protein

Necrosis, steatosis and fatty change of hepatic cells

31

Lawsonia inermis

Lythraceae

Root

Savara, Santhal

CCl4 induced

Leaves

  SGPT, SGOT, SGPT, SAKP, SB

Centizonal necrosis and steatosis

32

Moringa oleifera

Moringaceae

Root

Plain and tribes

Anti-tubercular drug induced

Leaves

SGPT, SGOT, SGPT, SB

 hepatic damage

33

Ocimum sanctum

Lamiaceae

Leaf

Kondha

Paracetamol induced

Leaves

serum proteins, albumin globulin ratio, alkaline phosphatase, transaminases

Reduction in sinusoidal congestion, cloudy swelling and fatty changes and regenerative areas of the liver

34

P. fraternus

Euphorbiaceae

Whole herb

Kondha

CCl4 induced

Leaves

SGOT, SGPT, ALP, Bilirubin and Cholesterol

Repair of hepatic tissue and stabilization plasma membrane

35

P. maderaspatensis

Euphorbiaceae

Whole herb

Kondha

CCl4 induced and thioacetamide induced

Whole plant

AST, ALT and LDH and liver lipid peroxides

Vacuolization, fatty changes and necrosis of hepatocytes

36

Phyllanthus amarus

Euphorbiaceae

Whole herb

Kondha

Ethanol induced

Aerial parts

ALT, AST, STG, HTG, tumor necrosis factor alpha, interleukin 1

Hepatocyte swelling, liver cell degeneration, active Kupffer cells and fatty liver

37

Ricinus communis

Euphorbiaceae

Root

Bhuyan

D - galactosamine induced

Leaves

ALT, AST, Alkaline phosphatase (ALP) and Malondialdehyde (MDA) level

congestion of cells, degeneration of central vein and portal vein, disruption of sinusoids and necrosis of hepatocytes

38

S. rhombifolia

Malvaceae

Root

Juang

Thioactamide and allyl alcohol induced

Roots

ALT, AST AND ASP

Necrosis and irreversible injury to liver tissue

39

Solanum indicum

Solanaceae

Root

Ho

CCl4 induced

Whole plant

ALP, SGOT, SGPT, TB

Liver cell necrosis with inflammatory collections and loss of cellular boundaries

40

Swertia angustifolia

Gentianaceae

Leaf

Santhal

Paracetamol induced

Aerial parts

GOT, GPT, ALP

Hepatic necrosis

41

Tephrosia purpurea

Fabaceae

Root

Saora

Thioacetamide induced

Aerial parts

ALP, AST, Total bilirubin

dose-dependent reduction of necrosis.

42

Tinospora cordifolia

Meninspermaceae

Root

Kondha

Cadmium induced

Stem

SOD, CAT GSH, GPx and GST

Vacuolization, fatty changes and necrosis of hepatocytes

43

Figure 1

Different location of tribes in Odisha

https://typeset-prod-media-server.s3.amazonaws.com/article_uploads/f66227e2-9e2d-42d5-933d-9b552bb9561f/image/721bbb24-cfba-40a2-87b3-229d9e8add6c-uimage.png

Figure 2

Plant parts of different family used in treatment of liver diseases

https://s3-us-west-2.amazonaws.com/typeset-prod-media-server/5619b6d9-bdbc-4049-8b3b-6e344b1efa7fimage2.png
Figure 3

Plant parts used by different tribes used in treatment of liver diseases

https://s3-us-west-2.amazonaws.com/typeset-prod-media-server/5619b6d9-bdbc-4049-8b3b-6e344b1efa7fimage3.png

These tribes use different parts of plant for treatment of liver diseases. Most of the tribal community44 maintain their culture, beliefs, customs, and tradition. They collect woods from different plants and also cultivate cereals, pulses and also use plants for treatment of aliments.

Nowadays developing countries are increasingly in an effort to prepare remedies for local health care systems and extensive research is underway to test the vast ethnobotanical knowledge of the treatment of various ailments. 45 More than 65% of the world's population in developing countries are dependent on phytomedicine for their treatment of aliments due to the easy availability and low cost of herbal medicines as suggested by the World health Organization. 46 The national community is usually engaged in agriculture and has sufficient knowledge of plants and their medicinal uses in the treatment of various foods 47 Due to deforestation and care less utilization of forests ethnomedicinal plants are under danger so it is essential to conserve valuable plants which are used as traditional medicine by the tribes 48 Odisha state is full of tribal people among which 62 tribes have been found to live in different forest pockets and districts of Odisha.49 A good number of medicinal plants have been identify from the various forest pockets region of odisha generally in the Similipal bio sphere reserve situated in Mayurbhanj district in that so many tribals people are residing and they are using different types of plant medicines. 50 The use of traditional medicine remains wide spread in developing countries while the use of complementary alternative medicine (CAM) is increasing rapidly 51.

Objectives and justification of research

  1. The present meta-analysis effort aims to represent the documented valuable ethno medicinal practices related to liver disease management and provide a collective information regarding herbs used in liver diseases.

  2. iThis report creates awareness among the herbal drug practitioners and scientific community by providing a comprehensive data related to respiratory disease management.

  3. This report give ideas about herbal remedies used by traditional healers or tribe for liver disease in different parts of Odisha.

Data presented 48 here is based on the outcome of field collection trips conducted during the period of 2016-17, in tribal domination forest areas. At least 3 collection trips were made to each tribal pocket in three different seasons. Information on the plant species was gathered from village headmen, knowledgeable informants and traditional healers. Interpreters were sought to facilitate conversation. Plant specimens49 were collected in the company of local informants to ensure that the proper plant had been obtained. The collected plants were correctly identified at IMMT Bhubaneswar, Odisha. All voucher specimens are deposited in the herbarium of the Institute.

Sl. No Tribal plant name plant used Nano Paticles characterization Inferenc

Result and discussion

In Odisha medicinal plants possess a distinctive position in folk medicine as well as their importance position in the sociocultural and spiritual arena of rural and tribal life in Odisha. This has helped traditional medicine and the use of medicinal plants to become an important part of Odisha’s cultural heritage. In Odisha, people in rural areas prefer treatment of various diseases by medicinal plants than by modern synthetic drugs which are expensive and because of difficulty to access medical services particularly in areas of conflicts and political instability. This review present data on 20 herbs evaluated scientifically as hepatoprotective using experimental models. From this review, it is clear that the medicinal plants play an important role in the treatment of a variety of conditions including liver diseases. Most medicinal plants are widely distributed in the rural areas.

Gold and silver nanoparticles used for antimicrobial and hepatoprotective activity Acacia catechu.

Conclusion

In this review

This review shows that some medicinal plants of Odisha have crucial role in protecting liver from chemical injuries using in vivo and in vitro models. Herbal drugs in Odisha play a vital role in the primary health care since 90 % of the Odisha people use medicinal plants to treat different diseases including liver disorders

Source of Funding

None.

Conflict of Interest

None.

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