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Synthesis and Antimicrobial Activity of Novel 5-Arylidene-3-(2-phenyl 4-oxo-1, 3-thiazolidine) succinimido aceto hydrazide Derivatives

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Original Article

Author Details : Pankaj Baboo, S.K.Gupta

Volume : 2, Issue : 3, Year : 2015

Article Page : 130-135

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Abstract

Ethyl N-Succinimido acetate was synthesized by equimolar condensation of succinimide and ethylchloroacetate by refluxing in presence of anhydrous potassium carbonate. Then Ethyl N-succinimido acetate was refluxed with hydrazine hydrate in presense of 1, 4-dioxane to obtain N-Succinimido acetylhydrazide, which was further treated with benzaldehyde to get phenyl succinimido acetylhydrazide, this compound was cyclized with mercaptoacetic acid to get the 3-(2-phenyl 4-oxo-1,3-thiazolidine) acetamido succinimide which was reacted with various aldehyde to get the 5-Arylidene-3-(2-phenyl 4-oxo-1,3-thiazolidine) succinimido aceto hydrazide. The formation of title compounds confirmed by physical and spectral data. The synthesized compounds were subjected to microbiological screening.

Keywords: Thiazolidinone derivatives, 5-Arylidene-3-(2-phenyl 4-oxo-1,3-thiazolidine) succinimido aceto hydrazide, antimicrobial activity.

How to cite : Baboo P, S.k.gupta, Synthesis and Antimicrobial Activity of Novel 5-Arylidene-3-(2-phenyl 4-oxo-1, 3-thiazolidine) succinimido aceto hydrazide Derivatives. Int J Pharm Chem Anal 2015;2(3):130-135

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