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Microwave assisted synthesis and pharmacological evaluation of few substituted 4-thiazolidinone derivatives

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Original Article

Author Details : Dinesh D. Rishipathak*, Poonam S.Wajpeyi, Sonal P. Tathe, Pavan B. Udavant

Volume : 6, Issue : 2, Year : 2019

Article Page : 44-48

https://doi.org/10.18231/j.ijpca.2019.008

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Abstract

In present investigation the synthesis of few 2-(substituted phenyl-3-(5-substituted phenyl-4H-1, 2, 4-triazole-3-yl)-thiazolidine-4-ones and 3-(5-(4-substituted phenyl)-1, 3, 4-thiadiazole-2-yl)-2-phenylthiazolidine-4-ones is reported with the aim of achieving enhanced anticonvulsant effect. Two schemes were designed viz. first scheme for clubbed triazole-thiazolidinone derivatives and second scheme for clubbed thiadiazole-thiazolidinone derivatives. The compounds were characterized on the basis of IR, ¹H-NMR and Mass analyses. Acute toxicity study was done to determine the LD₅₀ of the compounds. Some of the compounds were evaluated for their anticonvulsant activity using PTZ induced convulsions method. The compounds DCThizd-N and NMThizd-N showed highest percentage of protection (80%) at the dose of 30mg/kg among the evaluated compounds compared to control.

Keywords: 4-Thiazolidinone, Triazole, Thiadiazole, Anticonvulsant activity.

How to cite : Rishipathak D D, S.wajpeyi P, Tathe S P, Udavant P B, Microwave assisted synthesis and pharmacological evaluation of few substituted 4-thiazolidinone derivatives. Int J Pharm Chem Anal 2019;6(2):44-48

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