---

FTIR-spectrophotometric analysis of levosulpiride and its pharmaceutical formulations

Full Text PDF

---

Short Communication

Author Details : Sruthi K, Prasanth S.S*, Kamarunnisa K, Drisya N.K, Ashyam K

Volume : 5, Issue : 3, Year : 2018

Article Page : 151-155

https://doi.org/10.18231/2394-2797.2018.0025

Suggest article by email

Get Permission

Abstract

A fourier transform infrared (FTIR) spectrometric method was developed for the rapid, direct determination of levosulpiride in different pharmaceutical products.^1-3 The universal ATR spectra were recorded and used for this study. Multiple linear regression (MLR) where a restricted set of absorption band is used for calibration beer-lambert law was used for data processing. A recovery of 98.5% of levosulpiride from the tablet dosage form with a correlation coefficient of 0.996 was obtained. The aim of this study was to develop a FTIR spectrophotometric procedure for the analysis of levosulpiride in raw material and tablets. The linear regression equation for levosulpiride was calculated to be y=189.04+152.39*x where x and y are concentration and integrated peak area respectively. The method had excellent reproducibility for the standard of 50 mg, 49.5 ±1.02 mg (n =6). The recovery test is an experimental design to verify the relationship between the amount of substance added and the amount quantified by this assay. In this test the observed concentrations of pure levosulpiride in the powdered tablets were not significantly different from the stated concentrations by student's t test, p = 0.05% (100.04 ± 1.49%, n = 3) the method gave rise to linear data in the range 2-50. Mg with accuracy and precision in the range 0.77-3.2%. Therefore, this FTIR-spectrophotometric assay was accurate, and may be recommended for the simple quantification of levosulpiride.

Keywords: FTIR, Levosulpiride, ZnSe, AUC.

How to cite : Sruthi K, S.s P, Kamarunnisa K, N.k D, Ashyam K, FTIR-spectrophotometric analysis of levosulpiride and its pharmaceutical formulations. Int J Pharm Chem Anal 2018;5(3):151-155

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.