---

SOLUBILITY AND DISSOLUTION ENHANCEMENT OF GLICLAZIDE BY SOLID DISPERSION TECHNIQUE

Full Text PDF

---

Review Article

Author Details : More C.G, Dabhade P.S, Jain N.P, Aher B.O

Volume : 2, Issue : 2, Year : 2015

Article Page : 51-58

Suggest article by email

Get Permission

Abstract

The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Most NCE are poorly water soluble drugs, not well-absorbed after oral administration. Solid dispersion is an increasingly important approach to enhance dissolution rate and solubility of poorly water soluble drug. Gliclazide is a second generation hypoglycemic sulfonylurea which is useful in the treatment of non-insulin dependent diabetes mellitus (NIDDM). It exhibits slow GI absorption rate and inter individual variations of its bioavailability. Oral bioavailability of drug is 59%. Half-life of drug is about 10hr. Thus solubility enhancement and dissolution enhancement of Gliclazide from its dosage form is an important issue for its in vivo bioavailability and therapeutic efficacy. Therefore it was planned in this investigation to improve the solubility and bioavailability of drug by using different hydrophilic polymers. Also, it was planned to evaluate such solid dispersion formulations for their various pre-compression and compression characteristics, in vitro drug release kinetics and stability of the dosage forms.

Keywords: Non-insulin Dependent diabetes mellitus (NIDDM), New chemical Entities(NCE), Solid dispersion’s (SD’s)

How to cite : C.g M, P.s D, N.p J, B.o A, SOLUBILITY AND DISSOLUTION ENHANCEMENT OF GLICLAZIDE BY SOLID DISPERSION TECHNIQUE. Int J Pharm Chem Anal 2015;2(2):51-58

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.