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Design, synthesis and biological evaluation of novel thiadiazole derivatives as antihyperlipidemic agents

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Original Article

Author Details : Paul Jacob, Beena Thomas, Neethu Santhosh

Volume : 5, Issue : 1, Year : 2018

Article Page : 16-23

https://doi.org/10.18231/2394-2797.2018.0004

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Abstract

Thiadiazole derivatives are reported to have various biological activities including antihyperlipidemia. In the present study a series of N-phenyl-1, 3, 4-thiadiazol-2-amine derivatives were designed using various softwares like Molinspiration, Schrodinger etc. The derivatives with optimum properties were synthesized and characterized using FT-IR, ¹HNMR and MASS spectroscopy. In vivo screening for antihyperlipidemic activity in triton X-100 induced models showed moderate activity in comparison with standard.

Keywords: Thiadiazole, Antihyperlipidemia, Triton X-100, Atorvastatin.

How to cite : Jacob P, Thomas B, Santhosh N, Design, synthesis and biological evaluation of novel thiadiazole derivatives as antihyperlipidemic agents. Int J Pharm Chem Anal 2018;5(1):16-23

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