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Formulation, development and evaluation of fast disintegrating tablet of dapsone by using natural super disintegrates

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Original Article

Author Details : Nandhini M*, Suganya T Kumar, Yamuna R , Keerthika A , Sindhu C , Voleti Vijaya Kumar, Anisha B , P. Shanmugapandiyan

Volume : 11, Issue : 3, Year : 2024

Article Page : 239-244

https://doi.org/10.18231/j.ijpca.2024.034

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Abstract

The needof the fast-disintegrating tablets ever increasing day by day during the last decade. In this current research study, the effect of the natural super disintegrating agents in the Dapsone fast disintegrating tablets was compared. The natural super disintegrating agents were characterized for different physico chemical methods like Loss on drying, moisture content and Ash values.Dapsone was selected as a model drug, where the dapsone has low bioavailability due to this reason, dapsone solid dispersions were developed and the same was used to formulate the tablets. The formation of the solid dispersions was confirmed by the XRD studies. Dapsone solid dispersions showed the better solubility than to the pure dapsone.The dapsone FDT were prepared by use of the Direct compression method by use of the three natural super disintegrating tablets in different proportions. Total of 9 formulations were developed. The components were evaluated for the pre compressional parameters like Angle of repose, bulk density, tapped densityand post compressional parameters like drug content, hardness, weight variation, wetting time, friability, disintegration time, dissolution time, drug release study. The formulation F9 showed the lowest disintegration time, less wetting time, less dispersion time and in-vitro dissolution studies recorded that formulation F9 (Banana Powder) showed 99.43% drug release.It was proved that the formulations with highest concentration of the super disintegrating agents showed the highest drug release than to the lowest concentrations.

Keywords: Fast disintegrating tablets, Banana powder, Plantago ovata, fenugreek Seed Mucilage, In Vitro Dispersion time

How to cite : Nandhini M, Kumar S T, Yamuna R, Keerthika A, Sindhu C, Kumar V V, Anisha B, Shanmugapandiyan P , Formulation, development and evaluation of fast disintegrating tablet of dapsone by using natural super disintegrates. Int J Pharm Chem Anal 2024;11(3):239-244

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