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Comprehensive review on paracetamol: Efficacy, safety, and usage in modern medicine

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Review Article

Author Details : Suraj Kumar Sharma*, Karam Singh Tanty, Mukesh Pradhan

Volume : 11, Issue : 3, Year : 2024

Article Page : 226-231

https://doi.org/10.18231/j.ijpca.2024.032

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Abstract

In over-the-counter headache medications, N-acylated aromatic amines—those with an acyl group, RCO-substituted on nitrogen—play a significant role. Drugs that you can get over the counter don't require a prescription. Acetanilide, phenacetin, and paracetamol (acetaminophen) are the so-called "aniline derivatives" or "aniline analgesics," of which paracetamol is essentially the only survivor. Acetanilide is the precursor to both phenacetin and paracetamol. An industrial chemist may refer to paracetamol as 4-hydroxyacetanilide or para-hydroxy acetanilide. It is a crucial end product and precursor for synthesising several other organic chemicals. It has become well-known as an analgesic because of its accessibility, but when overeating or in combination with other foods or medications, it can have severe side effects. This article discusses the historical transformations this significant molecule has undergone up to this point, how chemists prepare it, the processes it goes through when other precursors are present, how much it doses, its adverse effects, and how it is used. This is a beneficial medication that should be handled carefully because it can become poisonous when used with other medicines, including warfarin.

Keywords: Phenacetin, Drug­Drug Interaction, Preparation, Naphthalene, Acetanilide, Paracetamol

How to cite : Sharma S K, Tanty K S, Pradhan M, Comprehensive review on paracetamol: Efficacy, safety, and usage in modern medicine. Int J Pharm Chem Anal 2024;11(3):226-231

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