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Role of ginsenosides in bone remodelling: A narrative review on molecular mechanism

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Review Article

Author Details : Joshi Ankur*, Soni Priyanka, Verma Poojashree, Khemani Purva, Vishwakarma Usha, Shaikh Gulfisha, Malviya Neelesh, Malviya Sapna, Kharia Anil

Volume : 11, Issue : 3, Year : 2024

Article Page : 188-197

https://doi.org/10.18231/j.ijpca.2024.028

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Abstract

Osteoporosis (OP) is a metabolic bone disease that impacts a large number of humanity. Degeneration of the bone microstructure, loss of mass, and heightened fragility are symptoms. The primary reason is because the rates of bone formation and resorption are different. Extensive research on the effects of ginsenoside, a component of ginseng used in traditional Indian medicine, on osteoporosis has shown promising results. There were forty-four articles written about ginsenosides, osteoblasts, osteoclasts, osteoporosis, and bone mesenchymal cells. The effects of ginsenosides on osteoblast, osteoclast, and mesenchymal stem cell activity in bone remodelling and their potential role in preventing osteoporosis were the focus of these studies. This in-depth study sheds light on the several ginsenosides used to treat osteoporosis from different perspectives, paving the way for potential therapeutic applications in the future.

Keywords: Osteoporosis (OP), Bone marrow stem cells (BMSCs), Peripheral nervous system (PNS)

How to cite : Ankur J, Priyanka S, Poojashree V, Purva K, Usha V, Gulfisha S, Neelesh M, Sapna M, Anil K, Role of ginsenosides in bone remodelling: A narrative review on molecular mechanism. Int J Pharm Chem Anal 2024;11(3):188-197

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