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Teneligliptin hydrobromide hydrate mouth dissolving strip: Formulation and evaluation

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Original Article

Author Details : S.M. Ghurghure, S.M. Attar*, Sumit

Volume : 11, Issue : 2, Year : 2024

Article Page : 164-170

https://doi.org/10.18231/j.ijpca.2024.023

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Abstract

Oral route is considered as one of the most convenient route for administration of various pharmaceutical dosage form like tablet, capsule, syrup, suspension and emulsion. Fast Dissolving Drug Delivery systems have developed various fast disintegrating preparations like Oral disintegrating film, ODF. Oral disintegrating film is the solid oral drug delivery system, in which water soluble polymer involve to disintegrate film into mouth fastly. Oral disintegrating film is superior as compare to orally disintegrating tablet as the cost of production is low. The present research was undertaken to develop oral disintegrating film of tteneligliptin hydrobromide hydrate to have rapid onset of action. of tteneligliptin hydrobromide hydrate which is an anti-diabetic. The mechanism action of Teneligliptin is to increase incretin levels (GLP-1 and GIP), which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels.The concept of formulating fast disintegrating film Teneligliptin containing offers a suitable and practical approach in serving desired objective of faster disintegration and dissolution characteristics with increased bioavailability. ODF of Teneligliptin were prepared by solvent casting method and evaluated physicochemical parameters like thickness, weight variation, moisture content, folding endurance, drug content, etc. All the formulations of Teneligliptin ODF displayed optimum folding endurance, which indicates the formulation prepared can withstand handling and transportation. From the results obtained, it was concluded that the formulation of oral disintegrating film has better physical chemical properties with good disintegration property.

Keywords: Teneligliptin hydrobromide hydrate, Oral disintegrating film, Insulin secretion, Disintegrating property

How to cite : Ghurghure S, Attar S, Sumit, Teneligliptin hydrobromide hydrate mouth dissolving strip: Formulation and evaluation. Int J Pharm Chem Anal 2024;11(2):164-170

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