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Evaluation of betulin for hair growth promoting activity in rats

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Original Article

Author Details : Vinay Vishnudas Sarode*, Sadhana P. Gautam

Volume : 11, Issue : 1, Year : 2024

Article Page : 62-71

https://doi.org/10.18231/j.ijpca.2024.009

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Abstract

Background: Hair has historically been associated with beauty and a person's unique personality. Numerous elements, including metabolism, hormones, inheritance, and the adverse effects of immunosuppressive and anti-neoplastic medications, can adversely impact hair health and lead to hair loss, or alopecia. It is typical everywhere in the world.
Aim: The current study examined the effect of betulin for hair growth promoting activity in rats.
Materials and Methods: The study used 48 albino wistar rats, weighing 200 ± 30 grams and aged between 12 and 16 months. Testosterone was given at a dose of 0.5 mg/kg to induce hair loss. During 28 days, a once-daily topical application of minoxidil solution was made. On a daily basis for 28 days, betulin was administered orally at concentrations of 10 mg/kg, 20 mg/kg, and 40 mg/kg. A combination of Betulin (10 mg/kg p.o.) and 3% Minoxidil was administered to one group, while the other was treated with Topical Betulin Solution (3 mg/ml once daily for 28 days). ANOVA analysis was used to ascertain the data's statistic.
Results: The results showed that effect of Betulin on Alopecia as evidenced by decreased levels of cholesterol, testosterone and increased levels of Hair length.
Conclusions: According to the current study, albino wistar rats with Testosterone induced Alopecia can benefit from treatment with an Betulin.

Keywords: Bitulin, Minoxidil, Testosterone, Alopecia, ANOVA

How to cite : Sarode V V, Gautam S P, Evaluation of betulin for hair growth promoting activity in rats. Int J Pharm Chem Anal 2024;11(1):62-71

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