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Simultaneous estimation of beclomethasone dipropionate and salbutamol sulphate in capsules by chemometric assisted UV-spectrophotometric method

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Original Article

Author Details : Santosh V. Gandhi, Akshay R. Pahade, Abhijeet S. Sutar, Bandudas S. Kuchekar, Shreeyash R. Tapale

Volume : 3, Issue : 2, Year : 2016

Article Page : 84-89

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Abstract

A convenient new method for simultaneous estimation of Beclomethasone dipropionate and Salbutamol sulphate, with minimum sample pretreatment is described in this paper. The procedure, based on the multivariate analysis of spectral data in the 220?260 nm region by the partial least squares method (based on SIMPLS algorithm) has been evaluated. The evaluation of calibration model is relied on the coefficient of determination (R²) and root mean square error of calibration (RMSEC). The coefficient of determination (R²) for the relationship between actual values and predicted values of both drugs was higher than 0.9930, indicating good accuracy of the developed method while RMSEC values (0.8637) obtained were relatively low which indicate acceptable precision of analytical method. The experimental calibration and validation matrixes were constructed with 55 and 24 samples, respectively. The concentration range considered was 10.0-60.0 ?g/ml for both the drugs. The method was successfully applied for estimation of drugs in pharmaceutical formulation, with no interference with excipients as indicated by the recovery studies. The proposed method is simple, rapid and can be easily used in the quality control of drugs as alternative analysis tools.

Key Words: Chemometric, Partial least square, Beclomethasone dipropionate, Salbutamol sulphate

 

How to cite : Gandhi S V, Pahade A R, Sutar A S, Kuchekar B S, Tapale S R, Simultaneous estimation of beclomethasone dipropionate and salbutamol sulphate in capsules by chemometric assisted UV-spectrophotometric method. Int J Pharm Chem Anal 2016;3(2):84-89

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