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Anti-inflammatory activity of novel xanthone derivatives

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Original Article

Author Details : Darakhshan Parveen*, Amrita Parle, Rajnish Srivastava

Volume : 8, Issue : 4, Year : 2021

Article Page : 174-181

https://doi.org/10.18231/j.ijpca.2021.034

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Abstract

As many diseases such as cancer, metabolic disorders, aging, and neurodegenerative diseases present themselves via inflammation,there is always a need to have better anti-inflammatory drugs. Xanthones, a unique scaffold with a 9H-Xanthen-9-one core structure possesses anti-inflammatory activity. This research work comprised of theoretically designing thirty 3-aminoalkoxy derivatives of xanthone, estimation of physicochemical properties and their Molecular Docking with COX-1 receptor. The best docking scores are possessed by LIG12, LIG23 and LIG30 which were halo substituted phenyl derivatives, LIG7 which had an anilino substitution and LIG27 which had ortho-nitro phenyl substituted derivative. The docking scores of LIG7, LIG12, LIG23, LIG27 and LIG30 were found to be -10.6, -10.7, -10.7, -10.8 and -10.5 kcal/mol.

Keywords: Xanthone Derivatives, Anti­inflammatory, Molecular Docking, 2D&3D interactions, COX­ 1

How to cite : Parveen D, Parle A, Srivastava R, Anti-inflammatory activity of novel xanthone derivatives. Int J Pharm Chem Anal 2021;8(4):174-181

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