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Analytical tools in protein structure determination

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Review Article

Author Details : Krishna R Gupta*, Uttam Patle, Uma Kabra, P. Mishra, Milind J Umekar

Volume : 8, Issue : 3, Year : 2021

Article Page : 103-111

https://doi.org/10.18231/j.ijpca.2021.021

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Abstract

Three-dimensional protein structure prediction from amino acid sequence has been a thought-provoking task for decades, but it of pivotal importance as it provides a better understanding of its function. In recent years, the methods for prediction of protein structures have advanced considerably. Computational techniques and increase in protein sequence and structure databases have influence the laborious protein structure determination process. Still there is no single method which can predict all the protein structures. In this review, we describe the four stages of protein structure determination. We have also explored the currenttechniques used to uncover the protein structure and highpoint best suitable method for a given protein.

Keywords: Protein, Structure, X­ray, NMR, Mass spectroscopy, Rosette

How to cite : Gupta K R, Patle U, Kabra U, Mishra P, Umekar M J, Analytical tools in protein structure determination. Int J Pharm Chem Anal 2021;8(3):103-111

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