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Medicinal mushroom: What should we know?
Introduction
Mushrooms, are now beginning to receive much deserved attention for their very real health giving qualities. Mushrooms grow wild in many parts of the world and are also commercially cultivated. Nutritionally, mushrooms are a valuable health food and have been used medicinally for centuries in many parts of the world.[1], [2], [3], [4], [5] Mushrooms are the reproductive phase (fruiting bodies) but they there is also a vegetative phase to these fungi (mycelia). Edible mushrooms are often low in calories and can be healthy sources of proteins, flavonoids, metals, amino acids, minerals, volatile oils, carotenoids fats, phenolic compounds, and different vitamins and ergosterol that can be used as a source for vitamin D2. Nowadays, medicinal mushrooms are regarded as functional foods and exist as over-the-counter health supplements used in complementary and alternative medicines.[6], [7], [8], [9], [10]
In ancient traditional medicines, medicinal mushrooms were occupying the headlines, and the main topics were confirming to their miraculous therapeutic powers. The presence of various phenolic compounds, polysaccharides, and terpenoids and other compounds, is the reason for their potent biological activities as anticancer, antioxidant, antimicrobial, antiviral, antiaging, hepatic protective, hypoglycemic, hypocholesterolemic, and much more biological activities are discovered every day.[11], [12], [13], [14], [15] Many mushroom genera are famous for their promising therapeutic capabilities. In most Asian countries, it was believed that medicinal mushrooms had the power to enhance long life and liveliness.[16], [17], [18], [19], [20]
A wide variety of compounds isolated from many species of mushrooms, have been identified,[21], [22], [23], [24], [25] most of them were fatty acids, terpenoids, proteins, phenols, lectins, steroids, and polysaccharides. Mushrooms have been reported to exhibit an assortment of biological activities including but not limited to anticancer, antimicrobial, hypocholesterolemic, antioxidant, antihypertensive, antidiabetic, anti-obesity, hepato-protective, antiaging, anti-allergic, and anti-coagulant activities.[26], [27], [28], [29] In this review, the different biological activities of some mushrooms have been discussed. Beside medicinal benefits mushroom mycelium-based offer a promising solution as a ‘green material’ for the environmental problems.[30], [31], [32]
Medicinal mushrooms as a new source of natural therapeutic bioactive compounds
Isolation and identification of bioactive compounds from mushrooms crude extracts are required in order to specify which compound is responsible of the activity. Various compounds are responsible for the therapeutic activities of many mushrooms genera. The main group of compounds will be highlighted as follows. Polysaccharides represent the major compounds existing in medicinal mushrooms, and they exhibit antioxidant, anticancer, antidiabetic, antiinflammatory, antimicrobial, and immunomodulatory activities.[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28] Glucan polysaccharides especially β-glucans have been reported to exhibit antimicrobial activity, hypoglycemic, and enhance immunity through the activating macrophages. Terpenes are the compounds responsible for the antioxidant, anticancer, and anti-inflammatory activities among many other biological activities exerted by mushrooms.[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28] Phenolic compounds are responsible for antioxidant activities in mushroom extracts through acting as decomposers of peroxidase, inactivators of metals, oxygen scavengers, or inhibitors of free radicals. A long list of phenolic compounds were isolated from mushrooms. On the other hand, mushrooms produce many bioactive proteins and peptides, such as lectins, fungal immunomodulatory proteins, ribosome-inactivating proteins, and laccases.[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28]
There are many genera of medicinal mushrooms known for their use as a source of therapeutic bioactive compounds. This review describes the importance of medicinal mushrooms with focus on Agaricus bisporus, Agaricus blazei, Pleurotus ostreatus, Coprinus comatus, Cantharellus cibarius, Tremella fuciformis, Flammulina velutipes, Grifola frondosa and Lentinula edodes as an examples of worldwide medicinal mushrooms.
Uses and Health Benefits of Agaricus Bisporus
Agaricus bisporus belongs to Basidiomycetes family and the most important commercially cultivated mushroom in the world. The rich nutrients like carbohydrates, proteins, lipids, fibers, minerals, and vitamins present this mushroom as famous healthy food. Moreover, because of the presence of some active ingredients, such as polysaccharides, lipopolysaccharides, essential amino acids, peptides, glycoproteins, nucleosides, triterpenoids, lectins, fatty acids and their derivatives. This mushroom has been reported to have antimicrobial, anticancer, antidiabetic, antihypercholesterolemic, antihypertensive, hepatoprotective and antioxidant activities.[33] Agaricus bisporus contains bioactive compounds that have been shown to exhibit immunomodulating and anticancer properties. The Canadian Cancer Society recommends consumption of Agaricus bisporus mushroom because of its effectiveness against human diseases. Agaricus bisporus contains high levels of dietary fibers and antioxidants including vitamin C, D, and B12; folates and polyphenols that may provide beneficial effects on cardiovascular and diabetic diseases.[34]
White Agaricus bisporus is the most popular and the most commonly eaten edible mushroom species in the world. It is popular not only because of its taste, but also due to its high level of nutrients: dietary fiber (chitin), essential, semi-essential amino acids, unsaturated fatty acids including linoleic and linolenic acids, easily digestible proteins, sterols, phenolic and indole compounds, and vitamins − especially provitamin D2 and B1, B2, B6, B7, and C. [35] Fruiting bodies of Agaricus bisporus have antioxidant, antibacterial, anti-inflammatory, antitumor, and immunomodulatory activity. The presence of antioxidant ergothioneine is also notable. Agaricus bisporus also contains derivatives of benzoquinone, a substance which belongs to the group of antibiotics.[35] Studies of tyrosinase isolated from this species show its very high similarity to human tyrosinase. This points directly to the fact that this species could be a rich source of tyrosinase used for medicinal and cosmetics purposes. Agaricus bisporus is also a rich source of selenium, zinc and other elements such as magnesium, copper, iron, potassium, sodium, calcium, phosphorus, sulfur or manganese.[35] Most of the investigations have shown that nutraceutical therapy is a promising source of new therapeutics against many life-threatening diseases. Although bioactive molecules isolated from Agaricus bisporus may represent an important advance for their characterization as a source of drugs, more clinical data are needed for the determination of medicinal benefits of Agaricus bisporus ([Figure 1]).
Uses and Health Benefits of Agaricus Blazei
Agaricus blazei mushrooms are the most potent natural immune supporters among mushrooms ([Figure 1]). This is because they have a high concentration of beta-glucans, a type of molecule that has been shown to stimulate the activation of immune system cells, like macrophages and other polymorphonuclear leukocytes. Agaricus blazei popularly known as Himematsutake in Japan, is a mushroom native to Brazil, and widely cultivated in Japan for its medicinal uses, so it is now considered as one of the most important edible and culinary-medicinal biotechnological species. It was traditionally used to treat many common diseases like atherosclerosis, hepatitis, hyperlipidemia, diabetes, dermatitis and cancer.[36] Agaricus blazei has been consumed by human for decades. Due to the popularity, it is increasingly cultivated in many countries for its supposed medicinal properties. Many scientific studies reported various medicinal benefits (Anti-cancer, anti-microbial antioxidant and anti-inflammatory activities).[36]
Uses and Health Benefits of Pleurotus Ostreatus
Consumption of Pleurotus ostreatus, an edible oyster mushroom rich in functional ingredients (β-glucans), may improve glucose and lipid metabolism, blood pressure, body weight and appetite sensations. Oyster mushroom has been classified as vegetable in world foods. It belongs to genus Pleurotus. Mushroom fits in very well with sustainable farming systems with huge medicinal and nutritional importance ([Figure 2]). Oyster mushroom is the rich source of protein, vitamins, minerals, fibre and other antioxidants like selenium protect body cells from damage that might lead to chronic diseases and help to strengthen the immune system. Oyster mushroom is low in calories, fat free Cholesterol free, Gluten free and very low in sodium. Increasing the consumption of oyster mushroom appears to decrease the risk of obesity, diabetes, cancer, heart disease, and increase the immunity system of body.[37] Patel et al.,[38] reported that bioactive compounds present in Pleurotus spp. includes: polysaccharides, lipopolysaccharides, proteins, peptides, glycoproteins, nucleosides, triterpenoids, lectins, lipids and their derivatives.
Oyster mushroom (Pleurotus ostreatus) is such a mushroom which is used both as food and medicine to ensure the fitness of body. It contains protein, carbohydrates, fat, fiber, water, different kinds of vitamins and minerals as well as secondary metabolites. Its statins are outstanding in decreasing the harmful plasma lipids and in reducing blood pressure thereby reducing the risk of cardiovascular diseases. The beta-glucan component of oyster stimulates the immune system of the body. This mushroom is also found to be effective and beneficial in diabetes, cancer, microbial infections.[39]
Uses and Health Benefits of Coprinus Comatus
Mushrooms have been used for centuries not only as food but also in traditional medicine as a source of components with pro‐health activity. One of the important medicinal mushroom is Coprinus comatus, also called shaggy mane, chicken drumstick mushroom, or lawyer's wig. In Asian countries, Coprinus comatus is approved as edible mushroom. Various studies showed many of the physiological activities, such as antioxidant, anticancer, antiandrogenic, hepatoprotective, antiinflammatory, antidiabetic, antiobesity, antibacterial, antifungal, antinematode, and antiviral ([Figure 3]).[40]
The young mushrooms of Coprinus comatus, before the gills start to turn black, are edible. This mushroom is cultivated in China as food. When young it is an excellent edible mushroom. It can be used as a hypoglycemic food or medicine for hyperglycemic people. The hypoglycemic activity of fermented mushroom, Coprinus comatus tested on Alloxan and adrenalin-induced hyperglycemic mice. It confirmed that Coprinus comatus rich in vanadium has significant anti-hyperglycemic effect.[41]
Coprinus comatus, very common edible mushroom that grows in meadows in the presence of soils rich in organic matter. The most important medicinal property is the hypoglycemic property due to the high vanadium content and is useful in the treatment of type I and type II diabetes. It also contains a high amount of iron which balances the vanadium concentration. Coprinus comatus improves bowel function, promoting motility and blood circulation.[42] Kalaw and Albinto,[43] determine the nutraceutical and pharmacological potential of Philippine wild strain of Coprinus comatus. The antibacterial property, phytochemical composition, and antioxidant activity were also evaluated. Both ethanol and acetone basidiocarp extracts exhibited antibacterial activity against Staphylococcus aureus. Coprinus comatus ethanol extract produced wider zone of inhibition than acetone extract. Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins and terpenoids.[43] Researchers have discovered that Coprinus (Coprinus comatus) contains an excellent hypoglycaemic agent, colloidal vanadium, which helps to reduce high levels of blood sugar and glycated haemoglobin, the most important parameter in monitoring blood glucose trends.[44]
Uses and Health Benefits of Cantharellus Cibarius
Cantharellus cibarius is a species of golden chanterelle belonging to Family: Cantharellaceae. It is the most popular edible mushroom across almost every continent. The golden chanterelle mushroom, Cantharellus cibarius, is an edible mushroom with medicinal value. Given that this species has good radical scavenging activity and strong antioxidant potential and bactericidal effects.[45] Fruiting bodies of Cantharellus cibarius are a promising source of extracts with vitamins, carbohydrates, proteins, polysaccharides, sterols, phenolic acids, which various biological properties. This mushroom is also a highly valued source of carotenoids, tocopherols, vitamin C, flavonoids, sterols, phenolics, indole compounds and selenium. Some of these physiologically active compounds may be potentially used in dietary supplements or medicines.[46]
Cantharellus cibarius has been reported to display a wide variety of biological properties, including antimicrobial, cytotoxicity, antioxidant, antihypoxic, antihyperglycemic, wound healing, anti-inflammatory, iron-chelation activity.[47] Ethyl acetate, acetone, chloroform and ethanol extracts of Cantharellus cibarius were tested for antimicrobial activity ([Figure 4]). Antimicrobial activity against some Gram (+) and Gram (−) bacteria, yeasts, filamentous fungi and actinomycetes was revealed by Dulger et al.,[48] Polysaccharide is one of the important active ingredients of Cantharellus cibarius. Therefore, the investigation of the pro-health properties of crude polysaccharides from this genus and species was performed by many researchers.[24] The obtained results indicate that the polysaccharide fraction from Cantharellus cibarius inhibits the activity of both COX-1 and COX-2. Crude polysaccharides extracted from Cantharellus cibarius were found to inhibit the proliferation of colon cancer cells with the simultaneous absence of toxicity towards normal cells.[49]
The methanolic extract of the wild edible mushroom Cantharellus cibarius Fr. (chanterelle) was analyzed by Kozarski et al.,[50] for in vitro antioxidative, cytotoxic, antihypertensive and antibacterial activities. Various primary and secondary metabolites were found. Phenols were the major antioxidant components, followed by flavonoids, whose content was approximately 86% of the total phenol content. Antioxidant activity, measured by four different methods, was high for inhibition of lipid peroxidation and chelating ability. The extract showed good selectivity in cytotoxicity on human cervix adenocarcinoma HeLa, breast carcinoma MDA-MB-453 and human myelogenous leukemia K562, compared to normal control human fetal lung fibroblasts MRC-5 and human lung bronchial epithelial cells BEAS-2B. The extract revealed selective antimicrobial activity against Gram-positive bacteria with the highest potential against E. faecalis. The medicinal and health benefits, observed in wild Cantharellus cibarius mushroom, seem an additional reason for its traditional use as a popular delicacy food.[50]
Uses and Health Benefits of Snow Mushroom Tremella Fuciformis
For many years, traditional Chinese medicine has used mushrooms to treat various ailments. Tremella mushroom is has different famous names (Snow mushroom, silder ear mushroom, snow fungus or white jelly mushroom). Tremella fuciformis is a species of mushroom; it produces white, frond-like, gelatinous basidiocarps. The most important Tremella mushroom benefits are anti-aging, anti-inflammatory, lower cholesterol, combat obesity, protect nerves and may fight cancer. The most powerful nutritional constituents of Tremella are amino acids, vitamins, minerals, polysaccharides, Glucurmomannan 1,3-alpha-glucan, Epitope 9beta-D-glucuronosyl), Glucuronic acid, Glucurmic acid, Glucuronoxylomannan, N-acetylglucosamine, Flavonoids, Polyphenols, Alkaloids and Organic acids. Chinese consumers should choose nutritional and healthy food to maintain general health and reduce the risk of health problems. Nutrition therapy on the basis of traditional Chinese medicine such Tremella is quite effective at treating common diseases ([Figure 5]).[13] Tremella fuciformis belonging to the order of Tremellales and the family of Tremellaceae, which has been traditionally used for health promotion in China and other East Asian countries for many years. Plenty of bioactive substances are discovered in Tremella fuciformis, including fatty acids, proteins, enzymes, polysaccharides, phenols, flavonoid, dietary fiber and trace elements. Among them, Tremella fuciformis polysaccharide has been identified as a major bioactive component in Tremella fuciformis, widely existed in fruiting body, spores, mycelia and ferment liquor. Tremella fuciformis polysaccharide shows multiple physiological and healthy promoting effects, such as enhancing immune function, antitumor, anti-oxidation, anti-aging, hypoglycemic, hypolipidemic, neuroprotection and other effects.[51] Tremella fuciformis is naturally abundant in polysaccharides, which are a type of antioxidant that may contribute to anti-aging and antioxidant effects because of their ability to prevent cell damage caused by free radicals.[13]
Uses and Health Benefits of Enoki Mushroom Flammulina Velutipes
Enoki mushroom (Flammulina velutipes; family Physalacriaceae) is a popular, edible, and medicinal mushroom. Commonly known as Enokitake, golden needle mushroom, winter mushroom, lily mushroom, velvet stem, shank mushroom among different countries. Owing to its high nutritional value, aroma and delicious taste ranked 4th in terms of production and consumption in the world and mainly grown in Asian countries, especially China, Japan, Vietnam, and Korea. The most known benefits of Enoki mushrooms are anti-inflammatory, lowers cholesterol, and boost immunity.[52] Dietary fiber and mycosterol present in Enoki mushrooms can accelerate the decomposition of cholesterol. Therefore reduces total cholesterol, triacylglycerol, low-density lipoprotein in the serum, and liver.[52] Enoki mushroom is a potential source of Se supplementation and biotransformation. Selenium possesses beneficial effects on the protection of cells from free radicals and detoxification mechanisms. Thus Enoki mushroom is capable to balance selenite tolerance and reduction in the body.[53]
Flammulinol, flammulinolides, and polysaccharides found in the Enoki mushroom increase the proliferation and phagocytic activity of macrophages and prevent the building up of free radicals in the body. Thus intakes of Enoki mushroom (especially cap) possess antioxidants with cancer chemo-preventive properties.[54] Enoki mushroom is a rich source of polysaccharides that enhance the structure and function of the thymus and spleen. Which is important for T lymphocyte activation and maturation.[55] The presence of polysaccharides (glucan) in the Enoki mushroom shows the effect of the probiotic. It promotes the proliferation of intestinal bacteria, lactic acid, acetic acid, and other short-chain fatty acids. Thus stimulate peristalsis, increase stool moisture, improve intestinal motility, and improve constipation.[56] Enoki mushroom contains immunomodulatory protein which acts as an anti-inflammatory agent and inhibits house dust mite-induced asthma inflammation and therapeutic role for allergic airway diseases.[57] Enoki mushroom is a rich source of phenolic, flavonoids, and Sesquiterpenoids (terpenoids) that are responsible for protecting against different bacteria such as Escherichia coli, Bacillus subtilis, and Staphylococcus aureus.[58]
β-glucan and fatty acid complexes of the Enoki mushroom inhibit digestion and absorption of fats in the digestive tract and reduce the reabsorption of bile acid by breaking down fats. [58] The presence of high potassium and low sodium contents of the Enoki mushroom may be helpful in lowering blood pressure and reduce the risk of stroke in people with hypertension. [59] Flammulina velutipes is one of the most popular edible mushrooms due to its biological activities. Its chemical composition is optimal to provide physiology functions of organism with matters and energy. Many researches reported that Flammulina velutipes has various bioactive compounds such as polysaccharides, protein-glucan complex, sterols, lectins, peroxidases, proteases and others, these bioactive compounds showed different bioactivities, immunomodulating, antitumor, antioxidant, antihypertensive, antibacterial, antifungal, antiviral and other effects 60. Popovych et al.,[60] reported that Flammulina velutipes medicinal mushroom’s usage as a source of bioactive compounds for medicinal and preventive facilities, food and dietary supplements is a perspective direction of pharmaceutical technology. According to the Yeh et al.,[52] Flammulina velutipes contains biologically active components such as dietary fiber, polysaccharide, and mycosterol, whose effects in reducing blood sugar, blood pressure, and cholesterol have been confirmed ([Figure 6]).
Uses and Health Benefits of Maitake Mushroom Grifola Frondosa
Grifola frondosa (G. frondosa), generally known as hen-of-the-woods or maitake in Japanese and hui-shu-hua in Chinese, is an edible mushroom with both nutritional and medicinal properties. The fruiting bodies of maitake mushrooms are rich in polysaccharides, in particular beta-glucans, with one portion of these complex sugars known as maitake’s “D-fraction”. These powerful compounds activate a host defence response by stimulating the proliferation of immune cells such as macrophages, T-cells, natural killer cells and neutrophils ([Figure 7]). These cells will help the immune system to rapidly and efficiently fight against illness, increase resistance against sickness and disease, help the body to remove cellular waste and speed up recovery from tissue damage. The polysaccharides found in maitake mushrooms are also helpful to those undergoing heavy treatment for life threatening illnesses and have been reported to reduce the side effects of certain treatments.[61], [17]
Numerous studies have confirmed that the biological functions of Grifola frondosa extract, include immune regulation, antitumor, anti-aging, antivirus and reducing blood lipid activities. With better purification methodologies and with a better understanding of mechanisms of action Grifola frondosa has the potential to become an important biological modifier and an immune modulator.[62] Over the past three decades, Grifola frondosa polysaccharides were shown to possess various promising bioactivities, mainly including antitumor and immunomodulation, anti-oxidation and hepatoprotection, anti-hyperglycemia, and meanwhile can effectively act on the skin and hematopoietic stem cells.[63]
Uses and Health Benefits of Lentinula Edodes
Lentinula edodes (Shiitake) is an edible medicinal mushroom worldwide cultivated for nutritional compounds and pharmacological properties.[64] It is well-known in Traditional Asian Medicine and marketed as food supplements. Lots of investigations are carried out on its significant therapeutic potential.[65] Secondary effects were recently highlighted when consumed raw or poorly cooked.[66] Shiitake, was investigated for nutritional interest and pharmacological properties as potential agent in the metabolic syndrome, cancer treatment as well as antimicrobial natural drug.[50] Lentinus edodes is used medicinally for diseases involving depressed immune function (Including AIDS), cancer, environmental allergies, fungal infection, frequent flu and colds, bronchial inflammation, heart disease, hyperlipidemia, hypertension, infectious disease, diabetes, hepatitis and regulating urinary inconsistencies. Antibiotic, anti-carcinogenic and antiviral compounds have been isolated from fruiting body, mycelia. [66]
Lentinula edodes polysaccharides strengthen the immune system, eliminate side effects of chemo and radiotherapy and have strong antitumor, antiviral and antibacterial properties.[67] Lentinula edodes is of interest to researchers due to its content of therapeutic compounds (Figure, 8). These substances have antitumor, antifungal, antibacterial, anti-inflammatory, hypocholesterolemic, antihypertensive, hypoglycaemic and antioxidant effects. [67] Lentinula edodes species is characterized by anti-inflammatory properties, and it was found that addition of Cu, Zn, or Se enhanced the anti-inflammatory properties of Lentinula edodes mycelial extracts, suggesting that the mycelium of Lentinula edodes may be used as a potential component in natural anti-inflammatory dietary supplement. [68]
Lentinan ([1], [3] beta-D-glucan), a polysaccharide isolated from shiitake, is thought to be responsible for many of the mushroom's beneficial effects. An injectable form of lentinan is used for cancer treatment in some countries, but it has not been evaluated in large studies. Lentin, the protein component of shiitake, exerts antifungal properties, inhibits proliferation of leukemic cells, and suppresses the activity of HIV-1 reverse transcriptase. [69] Studies of shiitake extracts suggest antiproliferative, immunostimulatory, hepatoprotective, antimutagenic, and anticaries effects in vitro and in mice. But a clinical trial failed to show any benefit of an oral shiitake extract in the treatment of prostate cancer. [70], [71]
Other Genera of Medicinal Mushrooms
There are many genera of medicinal mushrooms known for their use as a source of therapeutic bioactive compounds.
Conclusion
Being functional foods, mushrooms represent a productive source of bioactive compounds with countless therapeutic capabilities working toward preventing and controlling many diseases. Medicinal mushroom industry is strong and growing. Various products were commercialized for compounds originated from Agaricus bisporus, Agaricus blazei, Pleurotus ostreatus, Coprinus comatus, Cantharellus cibarius, Tremella fuciformis, Flammulina velutipes, Grifola frondosa and Lentinula edodes. The strong worldwide interest and value assigned to these medicinal mushrooms has led to a large range of commercial products. Medicinal mushrooms keep surprising us by their promising biological activities, in a way that encourage studying their effects in vitro and in vivo in order to discover their potent compounds to win the war with the currently spreading life-threatening diseases. Further researches are required in order to isolate and identify more new bioactive compounds responsible for such biological activities. Moreover, clinical trials and more in-vivo experiments have to be carried out to confirm new mushrooms’ capabilities as sources of compounds having medical applications.
Source of Funding
None.
Conflict of Interest
None.
References
- W A Elkhateeb, G M Daba, P W Thomas, T C Wen. Medicinal mushrooms as a new source of natural therapeutic bioactive compounds. Egypt Pharm J 2019. [Google Scholar] [Crossref]
- W A Elkhateeb, G M Daba, M Elnahas, P Thomas, M Emam. Metabolic profile and skin-related bioactivities of Cerioporus squamosus hydromethanolic extract. Biodiversitas J Biol Div 2020. [Google Scholar]
- W A Elkhateeb, G Daba. The endless nutritional and pharmaceutical benefits of the Himalayan gold, Cordyceps; Current knowledge and prospective potentials. Biofarmasi J Nat Product Biochem 2020. [Google Scholar]
- W A Elkhateeb, G M Daba. Termitomyces Marvel Medicinal Mushroom Having a Unique Life Cycle. Open Access J Pharm Res 2020. [Google Scholar]
- G M Daba, W Elkhateeb, A N Eldien, E Fadl, A Elhagrasi, W Fayad, T C Wen. Therapeutic potentials of n-hexane extracts of the three medicinal mushrooms regarding their anti-colon cancer, antioxidant, and hypocholesterolemic capabilities. Biodiversitas J Biol Diver 2020. [Google Scholar]
- W A Elkhateeb. What medicinal mushroom can do. Chem Res J 2020. [Google Scholar]
- W A Elkhateeb, G M Daba, E M Elmahdy, P W Thomas, T C Wen, Mohamed N. Antiviral potential of mushrooms in the light of their biological active compounds. ARC J Pharmac Sci 2019. [Google Scholar] [Crossref]
- A El-Hagrassi, G Daba, W Elkhateeb, A E El-Dein, A N Fayad, W Shaheen. In vitro bioactive potential and chemical analysis of the n-hexane extract of the medicinal mushroom, Cordyceps militaris. Malays J Microbiol 2020. [Google Scholar] [Crossref]
- W A Elkhateeb, G M Daba, A N El-Dein, D H Sheir, W Fayad, M N Shaheen. Insights into the in-vitro hypocholesterolemic, antioxidant, antirotavirus, and anticolon cancer activities of the methanolic extracts of a Japanese lichen, Candelariella vitellina, and a Japanese mushroom. Egyp Pharm J 2020. [Google Scholar] [Crossref]
- W A Elkhateeb, M O Elnahas, P W Thomas, G M Daba. To Heal or Not to Heal? Medicinal Mushrooms Wound Healing Capacities. ARC J Pharm Sci 2019. [Google Scholar]
- W A Elkhateeb, G M Daba, E Mo, P W Thomas. Anticoagulant capacities of some medicinal mushrooms. ARC J Pharma Sci 2019. [Google Scholar] [Crossref]
- W Elkhateeb, M O Elnahas, P W Daba. Fomes fomentarius and Polyporus squamosus models of marvel medicinal mushrooms. Biomed Res Rev 2020. [Google Scholar]
- W A Elkhateeb, G M Daba. Mycotherapy of the good and the tasty medicinal mushrooms Lentinus, Pleurotus, and Tremella. J Pharm Pharmacol Res 2021. [Google Scholar]
- W A Elkhateeb, G M Daba. The Fascinating Bird’s Nest Mushroom. Int J Pharma Res and Health Sci 2021. [Google Scholar]
- W A Elkhateeb, G M Daba, S M Gaziea. The Anti-Nemic Potential of Mushroom against Plant-Parasitic Nematodes. J Microbiol Biotech 2021. [Google Scholar]
- W A Elkhateeb, M O Elnahas, T Pw, G M Daba. Trametes Versicolor and Dictyophora Indusiata Champions of Medicinal Mushrooms. J Pharm Res 2020. [Google Scholar]
- W A Elkhateeb, G Daba. The endless nutritional and pharmaceutical benefits of the Himalayan gold, Cordyceps; Current knowledge and prospective potentials. J Nat Prod Biochem 2020. [Google Scholar]
- G M Daba, W Elkhateeb, A N Eldien, E Fadl, A Elhagrasi, W Fayad. Therapeutic potentials of n-hexane extracts of the three medicinal mushrooms regarding their anti-colon cancer, antioxidant, and hypocholesterolemic capabilities. J Biol Diver 2020. [Google Scholar]
- P W Thomas, W A Elkhateeb, G M Daba. Chaga (Inonotus obliquus): a medical marvel but a conservation dilemma. Sydowia 2020. [Google Scholar] [Crossref]
- W Elkhateeb, P Thomas, M Elnahas, G Daba. Hypogeous and Epigeous Mushrooms in Human Health. Adv Macrofungi 2021. [Google Scholar] [Crossref]
- W A Elkhateeb, D E El Ghwas, N R Gundoju, T Somasekhar, M Akram, G M Daba. Chicken of the Woods Laetiporus Sulphureus and Schizophyllum Commune Treasure of Medicinal Mushrooms. Open Access J Microbiol Biotechnol 2021. [Google Scholar]
- W A Elkhateeb, G M Daba. Highlights on Unique Orange Pore Cap Mushroom Favolaschia Sp. and Beech Orange Mushroom Cyttaria sp. and Their Biological Activities. J Pharm Res 2021. [Google Scholar]
- W A Elkhateeb, G M Daba. Highlights on the Wood Blue-Leg Mushroom Clitocybe Nuda and Blue-Milk Mushroom Lactarius Indigo Ecology and Biological Activities. J Pharm Res 2021. [Google Scholar] [Crossref]
- W A Elkhateeb, G M Daba. Highlights on the Golden Mushroom Cantharellus cibarius and unique Shaggy ink cap Mushroom Coprinus comatus and Smoky Bracket Mushroom Bjerkandera adusta Ecology and Biological Activities. J Mycol Mycol Sci 2021. [Google Scholar] [Crossref]
- P W Thomas, W A Elkhateeb, G Daba. Truffle and truffle-like fungi from continental Africa. . Acta mycologica 2019. [Google Scholar]
- A G Alkolaibe, W A Elkhateeb, M O Elnahas, M E Manawaty, C Y Deng, Tc. Wound Healing, Anti-pancreatic Cancer, and α-amylase Inhibitory Potentials of the Edible Mushroom, Metacordyceps neogunnii. Res J Pharm Technol 2021. [Google Scholar]
- W A Elkhateeb, El-Ghwas. A Review on Ganoderic Acid, Cordycepin and Usnic Acid, an interesting Natural Compounds from Mushrooms and Lichens. Sci Nat 2021. [Google Scholar]
- W A Elkhateeb, G M Daba. The coral mushrooms Ramaria and Clavaria. Studies in Fungi 2021. [Google Scholar]
- P Thomas, W A Elkhateeb, G M Daba. Industrial Applications of Truffles and Truffle-like Fungi. Adv Macrofungi 2021. [Google Scholar]
- W Elkhateeb, M Elnahas, G Daba. Infrequent Current and Potential Applications of Mushrooms. 2021. [Google Scholar]
- W A Elkhateeb, G M Daba. The amazing potential of fungi in human life. ARC J Pharma Sci AJPS 2019. [Google Scholar]
- W A Elkhateeb, G M Daba. Muskin the Amazing Potential of Mushroom in Human Life. J Mycol Mycol Sci 2022. [Google Scholar]
- F Atila, M N Owaid, M A Shariati. The nutritional and medical benefits of Agaricus bisporus: a review. Biotechnol Food Sci 2021. [Google Scholar]
- S C Jeong, Y T Jeong, B K Yang, R Islam, S R Koyyalamudi, G Pang. White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nutr Res 2010. [Google Scholar] [Crossref]
- B Muszynska, K Kala, J Rojowski, A Grzywacz, W Opoka. Composition and biological properties of Agaricus bisporus fruiting bodies-a review. J Food and Nutr Sci 2017. [Google Scholar] [Crossref]
- F Firenzuoli, L Gori, G Lombardo. The medicinal mushroom Agaricus blazei Murrill: review of literature and pharmaco-toxicological problems. Evid Based Complement Altern Med 2008. [Google Scholar] [Crossref]
- K Deepalakshmi, M Sankaran. Pleurotus ostreatus: an oyster mushroom with nutritional and medicinal properties. J Biochem Technol 2014. [Google Scholar]
- Y Patel, R Naraian, V K Singh. Medicinal properties of Pleurotus species (Oyster mushroom): a review. J Fungal Plant Biol 2012. [Google Scholar]
- F R Mowsurni, M B Chowdhury. Oyster mushroom: Biochemical and medicinal prospects. Bangladesh J Med Biochem 2010. [Google Scholar]
- P Nowakowski, S K Naliwajko, R M Żukowska, M H Borawska, K Socha. The two faces of Coprinus comatus, Functional properties and potential hazards. Phytotherapy Res 2020. [Google Scholar]
- C Han, T Liu. A comparison of hypoglycemic activity of three species of basidiomycetes rich in vanadium. Biol Trace Element Res 2009. [Google Scholar]
- De Silva, D D Rapior, S Hyde, K D Bahkali. Medicinal mushrooms in prevention and control of diabetes mellitus. Fungal Diversity 2012. [Google Scholar]
- S P Kalaw, R F Albinto. Functional activities of Philippine wild strain of Coprinus comatus (OF Müll.: Fr.) Pers and Pleurotus cystidiosus OK Miller grown on rice straw based substrate formulation. Mycosphere 2014. [Google Scholar]
- C Han, J Yuan, Y Wang, L Li. Hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium. J Trace Elements Med Biol 2006. [Google Scholar]
- D Nasiry, A R Khalatbary, M A Ebrahimzadeh. Anti-inflammatory and wound-healing potential of golden chanterelle mushroom, Cantharellus cibarius (Agaricomycetes). Int J Med Mushrooms 2017. [Google Scholar]
- B Muszyńska, K Kała, A Firlej, K S Ziaja. Cantharellus cibarius: culinary-medicinal mushroom content and biological activity. Acta Poloniae Pharm Drug Res 2016. [Google Scholar]
- V Vlasenko, D Turmunkh, E Ochirbat, D Budsuren, K Nyamsuren, J Samiya. Medicinal potential of extracts from the chanterelle mushroom, Cantharellus cibarius (Review) and prospects for studying its strains from differs plant communities of ultracontinental regions of the Asia. BIO Web of Conferences 2019. [Google Scholar] [Crossref]
- B Dulger, A Gonuz, F Gucin. Antimicrobial activity of the macrofungus Cantharellus cibarius. Pak J Biol Sci 2004. [Google Scholar]
- N Nowacka-Jechalke, R Nowak, M Juda, A Malm, M Lemieszek, W Rzeski, Z Kaczyński. New biological activity of the polysaccharide fraction from Cantharellus cibarius and its structural characterization. Food chemistry 2018. [Google Scholar]
- M Kozarski, A Klaus, J Vunduk, Z Zizak, M Niksic, D Jakovljevic. Nutraceutical properties of the methanolic extract of edible mushroom Cantharellus cibarius (Fries): primary mechanisms. Food Function 2015. [Google Scholar] [Crossref]
- W Meihong. The Study on Development of Tremella fuciformis Berk Polysaccharide.. Int J Immunopathol Pharmacol. 2008. [Google Scholar]
- M Y Yeh, W C Ko, L Y Lin. Hypolipidemic and antioxidant activity of enoki mushrooms (Flammulina velutipes). Biomed Res Int 2014. [Google Scholar] [Crossref]
- J Wang, B Wang, D Zhang, Y Wu. Selenium uptake, tolerance and reduction in Flammulina velutipes supplied with selenite. PeerJ 2016. [Google Scholar]
- M Y Leung, K P Fung, Y M Choy. The isolation and characterization of an immunomodulatory and anti-tumor polysaccharide preparation from Flammulina velutipes. Immunopharmacol 1997. [Google Scholar] [Crossref]
- Z F Yan, N X Liu, X Mao, Y Li, C Li. Activation effects of polysaccharides of Flammulina velutipes mycorrhizae on the T lymphocyte immune function. J immunol Res 2014. [Google Scholar] [Crossref]
- X Xin, K Zheng, Y Niu, M Song, W Kang. Effect of Flammulina velutipes (golden needle mushroom, Enokitake) polysaccharides on constipation. Open Chem 2018. [Google Scholar]
- P Y Chu, H Sun, J Ko, M Ku, L Lin, Y Lee, K Lue. Oral fungal immunomodulatory protein-Flammulina velutipes has influence on pulmonary inflammatory process and potential treatment for allergic airway disease: a mouse model. Immunol Infect 2017. [Google Scholar]
- N Miyazawa, H Yoshimoto, S Kurihara, T Hamaya, F Eguchi. Improvement of diet-induced obesity by ingestion of mushroom chitosan prepared from Flammulina velutipes. J Oleo Sci 2018. [Google Scholar]
- C Tang, P C Hoo, L Tan, P Pusparajah, T Khan, L Lee. Golden needle mushroom: a culinary medicine with evidenced-based biological activities and health promoting properties. Front pharmacol 2016. [Google Scholar] [Crossref]
- V P Popovych, N O Koziko, T A Butkevych. Prospects of medicinal mushroom Flammulina velutipes usage in medical and pharmaceutical practices. Farmatsevtychnyi Zhurnal 2015. [Google Scholar]
- J Y Wu, K C Siu, P Geng. Bioactive Ingredients and Medicinal Values of Grifola frondosa (Maitake). . Foods 2021. [Google Scholar] [Crossref]
- Y He, L Zhang, H Wang. The biological activities of the antitumor drug Grifola frondosa polysaccharide. Prog Mol Biol Transl Sci 2019. [Google Scholar] [Crossref]
- X He, X Wang, J Fang, Y Chang, N Ning, H Guo. Polysaccharides in Grifola frondosa mushroom and their health promoting properties: A review. Int J Biol Macromolecules 2017. [Google Scholar] [Crossref]
- T C Finimundy, J A Henriques, A J Dillon. A Review on General Nutritional Compounds and Pharmacological Properties of the Lentinula edodes Mushroom. Food Nutr Sci 2014. [Google Scholar] [Crossref]
- N Zhang, H Chen, Y Zhang. Comparative studies on chemical parameters and antioxidant properties of stipes and caps of shiitake mushroom as affected by different drying methods. J Sci Food Agriculture 2013. [Google Scholar] [Crossref]
- P S Bisen, R K Baghel, B S Sanodiya, G S Thakur, G B Prasad. Lentinus edodes: a macrofungus with pharmacological activities. Curr Med Chem 2010. [Google Scholar] [Crossref]
- V P Rincão, K Yamamoto, N M Ricardo, S Soares, L D Meirelles, C Nozawa. Polysaccharide and extracts from Lentinula edodes: structural features and antiviral activity. Virol J 2012. [Google Scholar] [Crossref]
- B Muszyńska, K Kała, A Włodarczyk, A Krakowska, B Ostachowicz, J G Argasińska. Lentinula edodes as a source of bioelements released into artificial digestive juices and potential anti-inflammatory material. Biol Trace Element Res 2020. [Google Scholar] [Crossref]
- T Okamoto, R Kodoi, Y Nonaka, I Fukuda, T Hashimoto, K Kanazawa. Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver. Biofactors 2004. [Google Scholar] [Crossref]
- S Akamatsu, A Watanabe, M Tamesada, R Nakamura, S Hayashi, D Kodama. Hepatoprotective effect of extracts from Lentinus edodes mycelia on dimethylnitrosamine-induced liver injury. Biol Pharm Bull 2004. [Google Scholar] [Crossref]
- P H Ngai, T B Ng. Lentin, a novel and potent antifungal protein from shitake mushroom with inhibitory effects on activity of human immunodeficiency virus-1 reverse transcriptase and proliferation of leukemia cells. Life Sci 2003. [Google Scholar] [Crossref]
- Introduction
- Uses and Health Benefits of Agaricus Bisporus
- Uses and Health Benefits of Agaricus Blazei
- Uses and Health Benefits of Pleurotus Ostreatus
- Uses and Health Benefits of Coprinus Comatus
- Uses and Health Benefits of Cantharellus Cibarius
- Uses and Health Benefits of Snow Mushroom Tremella Fuciformis
- Uses and Health Benefits of Enoki Mushroom Flammulina Velutipes
- Uses and Health Benefits of Maitake Mushroom Grifola Frondosa
- Uses and Health Benefits of Lentinula Edodes
- Other Genera of Medicinal Mushrooms
- Conclusion
- Source of Funding
- Conflict of Interest