- Visibility 257 Views
- Downloads 45 Downloads
- Permissions
- DOI 10.18231/j.ijpca.2019.001
-
CrossMark
- Citation
Analytical techniques for Pirfenidone and Terizidone: A review
- Author Details:
-
Atul A. Shirkhedkar
-
Mohammad Mujeeb G Khan *
-
Prashant Chaudhari
-
Pritam I. Pawara
Pirfenidone is a broad-spectrum antifibrotic medicine. In 2014, it was approved for the treatment of the idiopathic pulmonary fibrosis (IPF) by the U.S. Food and Drug Administration. Terizidone is WHO categorized group IV anti TB drug. It is an antibiotic effective against Mycobacterium tuberculosis and also M. avium for the treatment of tuberculosis, both pulmonary and extra pulmonary. The fundamental aim of this article to assemble all reported analytical methods for qualitative and quantitative analysis of Pirfenidone and Terizidone in pharmaceutical formulation as well as in biological fluids. It consist of Spectroscopy, high performance liquid chromatography, High performance thin layer chromatography.
Keywords: Pirfenidone, Terizidone, Antifibrotic, Idiopathic pulmonary fibrosis, Analytical method.
References
- Guo, Jingwen. "Pirfenidone inhibits epithelial-mesenchymal transition and pulmonary fibrosis in the rat silicosis model." Toxicol letters 2019;300:59-66.
- Jiang, Nan. "The role of pirfenidone in alkali burn rat cornea." Int Immunopharmacology 2018;64:78-85.
- Taniguchi, H. "Pirfenidone in idiopathic pulmonary fibrosis." Eur Respir J 2010;35(4):821-9.
- Arata Azuma, Pirfenidone treatment of idiopathic pulmonary fibrosis
- Vora, Agam. "Mechanism of action." JAPI 2010;58:127.
- M.R.Siddiqui, Z.A.AlOthman, N.Rahman,. Analytical techniques in pharmaceutical analysis: A review. Arab J Chem 2017;10:S1409-S21
- K. Desai, A Patel, DR B Patel, K Desai. Method development and validation for estimation of Pirfenidone by UV- Spectrophotometric and RP-HPLC in tablet dosage form. IJPR
- K. Desai, A Patel, B Patel, K Desai. Method development and validation for estimation of Pirfenidone by UV- Spectrophotometric and RP-HPLC in tablet dosage form. IJPR
- Thorat, S. G. "Development and Validation of simple, rapid and sensitive UV, HPLC and HPTLC methods for the estimation of Pirfenidone in tablet dosage form." J Chilean Chem Soc 2016;61(2):2978-81.
- Parmar, VK., Desai SB, and Vaja T. "RP-HPLC and UV spectrophotomertic methods for estimation of pirfenidone in pharmaceutical formulations." Indian j Pharm Sci 2014;76(3):225.
- Jain, Hemant K., and Rahul R. Mane. "Estimation of Terizidone in Bulk and Capsule Dosage form by Area Under Curve and First Order Derivative Spectrophotometry." Int j PharmTech Res 2016;9(9)457-64.
- Khairnar, S., M. Nagras, and A. Sonawane. "Development and validation of UV spectrophotometric method for the estimation of terizidone in bulk and pharmaceutical dosage form." Inventi Rapid: Pharm Anal Qual Assurance 2016;3:1-4.
- M.R.Siddiqui, Z.A.AlOthman, N.Rahman,. Analytical techniques in pharmaceutical analysis: A review. Arab J Chem 2017;10:S1409-S21
- P.Ravisankar, A novel validated RP-HPLC Method for the determination of pirfenidone in pharmaceuyical dosage forms.
- 19-29
- Bodempudi, Suresh Babu, Ravichandra Babur, and Konda Srinivasa Reddy. "Development and substantiation of a RP- HPLC method for monitoring of impurities in pirfenidone drug substance." Am J Analytical Chem 2015;6(13):1019.
- K. Desai, A Patel, B Patel, K Desai. Method development and validation for estimation of Pirfenidone by UV- Spectrophotometric and RP-HPLC in tablet dosage form. IJPR
- Rajasekaran, A., and M. Deepthi. "Analytical Method Development and Validation of isocratic RP-HPLC separation of Pirfenidone and Robustness testing by Chemometric Atul A. Shirkhedkar et al. Analytical techniques for Pirfenidone and Terizidone: A review International Journal of Pharmaceutical Chemistry and Analysis, January-March, 2019;6(1):1-5 5 Analysis." Inventi Impact: Pharm Analysis & Quality Assurance 2014.
- Parmar, V. K., S. B. Desai, and T. Vaja. "RP-HPLC and UV spectrophotometric methods for estimation of pirfenidone in pharmaceutical formulations." Indian j Pharm Sci 2014;76(3):225.
- Thorat, S. G. "Development and Validation of simple, rapid and sensitive UV, HPLC and HPTLC Methods for the estimation of Pirfenidone in tablet dosage form." J Chilean Chem Soc 2016;61(2):2978-81.
- Wang, Yongsheng. "Simple determination of pirfenidone in rat plasma via high‐performance liquid chromatography." Biomed Chromatography 2006;20(12):1375-9.
- Kurian, Dona Sara, and Sara Kurian. Bioanalytical Method Development and Validation of Pirfenidone by Rp-Hplc Method and its Application to the Determination of Drug Food Interaction Study in Wister Rats. Diss. KMCH College of Pharmacy, Coimbatore, 2012.
- Santosh V. Gandhi, Development and Validation of a Stability Indicating RP-HPLC Method for the Determination of Terizidone, Indo Am J P Sci 2018;5(3).
- M.R.Siddiqui, Z.A.AlOthman, N.Rahman,. Analytical techniques in pharmaceutical analysis: A review. Arab J Chem 2017;10:S1409-S21.
- Thorat, Sonali G. "A validated stability-indicating high- performance thin-layer chromatographic method for the estimation of pirfenidone in tablet formulation." JPC-J Planar Chromatography-Modern TLC 2015;28(5):398-401.
- Mulubwa, Mwila, and Pierre Mugabo. "Analysis of terizidone in plasma using HPLC‐UV method and its application in a pharmacokinetic study of patients with drug‐resistant tuberculosis." Biomed Chromatography 2018;32(11):e4325.
How to Cite This Article
Vancouver
Shirkhedkar AA, Khan MMG, Chaudhari P, Pawara PI. Analytical techniques for Pirfenidone and Terizidone: A review [Internet]. Int J Pharm Chem Anal. 2019 [cited 2025 Oct 25];6(1):1-5. Available from: https://doi.org/10.18231/j.ijpca.2019.001
APA
Shirkhedkar, A. A., Khan, M. M. G., Chaudhari, P., Pawara, P. I. (2019). Analytical techniques for Pirfenidone and Terizidone: A review. Int J Pharm Chem Anal, 6(1), 1-5. https://doi.org/10.18231/j.ijpca.2019.001
MLA
Shirkhedkar, Atul A., Khan, Mohammad Mujeeb G, Chaudhari, Prashant, Pawara, Pritam I.. "Analytical techniques for Pirfenidone and Terizidone: A review." Int J Pharm Chem Anal, vol. 6, no. 1, 2019, pp. 1-5. https://doi.org/10.18231/j.ijpca.2019.001
Chicago
Shirkhedkar, A. A., Khan, M. M. G., Chaudhari, P., Pawara, P. I.. "Analytical techniques for Pirfenidone and Terizidone: A review." Int J Pharm Chem Anal 6, no. 1 (2019): 1-5. https://doi.org/10.18231/j.ijpca.2019.001