Formulation and evaluation of sustained release mucoadhesive microspheres of lornoxicam by using novel isolated polymer of fruit artocarpus heterophyllus

• Author Details:   
• Bebee Pathare
• Vrushali Tambe
• Dnyaneshwari Waichal
• Rahul Chanshetti
• Rohini Pujari

Objective: To investigate the potential of novel polymer isolated from fruit Artocarpus heterophyllus for mucoadhesion and sustained release action. Microspheres containing Lornoxicam formulated using isolated polymer offered a suitable, practical approach to achieve a prolonged therapeutic anti-inflammatory effect by continuously releasing the medication over extended period of time.
Materials and Methods: D-Optimal design was applied to optimize the fruit polymer and sodium tripolyphosphate concentration which was used as a cross-linking agent.
Result: Fruit polymer and sodium tripolyphosphate concentration has significant impact on % entrapment efficiency, mucoadhesivity, and in vitro release. Differential scanning calorimetry and infrared spectroscopy results indicates that no interaction between drug and excipients. Polynomial models were validated using one way ANOVA and results indicated that isolated fruit polymer and sodium tripolyphosphate used have significant effect on selected response (p<0.05). Contour plots and three dimensional response surface curves were drawn. In vivo studies were carried out for the optimized formulation. Furthermore, the pharmacokinetic parameters of the Lornoxicam microspheres showed constant release with minimum fluctuation in plasma drug concentration. The in vivo pharmacokinetic studies clearly demonstrate that microspheres of Lornoxicam shows sustained release action for 24 hrs.
Conclusion: From the result of the present work, it was concluded that preparation of Lornoxicam loaded microspheres by ionic gelation technique using novel isolated polymer from fruit of Artocarpus heterophyllus might be promising approach for sustained release mucoadhesive formulations.

Keywords: Artocarpus heterophyllus, Ionic gelation, In-vivo, Mucoadhesion.