- Visibility 91 Views
- Downloads 54 Downloads
Formulation and evaluation of lornoxicam emulgel
- Author Details:
-
Sonali P. Mahaparale
-
Vikas Gaware
Transdermal route of administration of drug is effective route of administration for different kind of indications. The purpose of present investigation was to develop Lornoxicam emulgel for systemic effect and to avoid side effects and minimize frequency of administration. Lornoxicam (NSAIDS) is a cox-1 and cox-2 inhibitor used in the treatment of pain, inflammations rheumatoid arthritis. Emulgel of lornoxicam was formulated using triethanolamine (5%) as solvent, carbopol 934 and carbopol 940 as gelling agents and various preservatives formulated gel was evaluated with respect to different physiochemical parameters such as ph, viscosity, Spreadability % drug content. All the prepared emulgel showed acceptable physical properties like homogeneity, colour, consistency, ph value, Grittiness, Spreadability, Extrudability % drug content. The results of in vitro drug release showed that carbopol 940 (0.4 gm) based emulgel gave better release. Also it was found that the gelling agent concentration had the most pronounced effect on the drug release from the emulgel.
Keywords: Lornoxicam, Carbopol, Hydroxyl Propyl methyl cellulose, Anti-inflammatory activity
References
- J. Patel, J. Trivedi, S. Choudary, Formulation and Evaluation of Diacerein Emulgel for Psoriatic Arthritis. Int. J Pharm. Res. Biosci, 2014, 3(2):625-638.
- U. Budhathoki, P. Thapa., Effect of chemical enhancers on in-vitro release of Salbutamol sulphate from transdermal patches. Kathmandu University J sci., Engineering and technology, 2005,1(1):1-8.
- M. N. Patel, P. D. Bharadia, M. M. Patel., Skin Penetration Enhancement Techniques: Physical Approaches. Int. J Pharm. and Applied Sci., 2010,1(2):62-72.
- J. Patel, J. Trivedi, S. Chaudhary, Formulation and evaluation of Diacerein emulgel for psoriatic arthritis research article. coden: Int. J. Pharm. Bio Sci., 2014,3(2):625-638
- B. Vaghela, N. Bhatt, N. Pathak, D. Rathod., Penetration enhancement technologies for transdermal drug delivery systems. Int.. J Pharm. Sci. Review and Research, 2011, 10(1), 130 -141.
- S. Baheti, K. Wadher, M. Umekar, A recent approach towards Transdermal Drug delivery by Physical and Chemical Techniques. Int Pharmaceutical Sciencia, 2011, 1(1): 42-53.
- R. Khullar, S. Saini, N. Seth, A. Rana, Emulgels: A surrogate approach for topically used hydrophobic drugs. Int. J. Pharmacy and Biological Sciences. 2011, 1:117-28.
- M. S. Mundada, S. S. Wankhede, S. K. Patwardhan, A. M. Avachat, Formulation & evaluation of Lornoxicam gel using a range of penetration enhancers. Indian J. Pharm. Education and research. 2013,47(2):168-70.
How to Cite This Article
Vancouver
Mahaparale SP, Gaware V. Formulation and evaluation of lornoxicam emulgel [Internet]. Int J Pharm Chem Anal. 2017 [cited 2025 Oct 23];4(3):83-87. Available from: https://doi.org/
APA
Mahaparale, S. P., Gaware, V. (2017). Formulation and evaluation of lornoxicam emulgel. Int J Pharm Chem Anal, 4(3), 83-87. https://doi.org/
MLA
Mahaparale, Sonali P., Gaware, Vikas. "Formulation and evaluation of lornoxicam emulgel." Int J Pharm Chem Anal, vol. 4, no. 3, 2017, pp. 83-87. https://doi.org/
Chicago
Mahaparale, S. P., Gaware, V.. "Formulation and evaluation of lornoxicam emulgel." Int J Pharm Chem Anal 4, no. 3 (2017): 83-87. https://doi.org/