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Formulation, Optimization and Characterization of Gastro-rententive Troxipide Microspheres
- Author Details:
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Manisha Karpe
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Monika Kumbhar
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Ravindra Tupe
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Gaurav Bhamare
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Vilasrao Kadam
Troxipide -loaded gastro retentive floating microspheres using Ethylcellulose as matrix and methanol as mucoadhesive polymer were prepared for the purpose of improving sustain drug release for about 12h of troxipide to produce local action and reduce dose frequency. The morphological properties of the microspheres were studied by optical microscopy and scanning electron microscopy (SEM). Floating microspheres are gaining attention due to their wide applicability in the targeting of drugs to the stomach. These floating microspheres have the advantage they remain buoyant and distributed uniformly over the gastric fluid to avoid the vagaries of gastric emptying and release the drug for prolonged periods of time. Multi-particulates low-density partices can successfully prolong the gastric retention time of the drugs. This article can provide an overview of two important approaches utilized to prepare and improve the performance of floating microspheres.
Keywords: GRDFs, FDDS, Hollow Microspheres, Troxipide, Sustain release, Local actions
References
- Martin A, Swarbrick J, Cammarata A. Physical Pharmacy. Physical chemical principles in the pharmaceutical sciences.3rd ed. Indian Edition. Mumbai: Varghese Publication House; 1991; p. 492–521.
- Phutane P, Shidhaye S, Lotlikar V, Ghule A, Sutar S, Kadam V. In vitro evaluation of novel sustained release microspheres of glipizide prepared by the emulsion solvent diffusion- evaporation method. Journal of Young Pharmacists 2010;2(1):35–41.
- Deveswaran R, Manavalan R, Madhavan V, Bharath S. Development and evaluation of aceclofenac loaded ethyl cellulose microspheres. Asian Journal of Pharmaceutical Sciences 2012;7(1):50–57.
- Jain P, Jain D, Verma S, Shukla SB, Jain AP, Yadav P. Formulation and evaluation of gastroretentive tablets of Furosemide(Evaluation based on drug release kinetics and factorial designs). Journal of Chemical and Pharmaceutical Research 2010;2(4):935–78.
- Bolton S, Bon C. Pharmaceutical Statistics – Practical and Clinical Applications – Drugs and the Pharmaceutical Sciences. Vol 135. 4th ed. New York: Marcel Dekker Inc.; 2004.p. 506–38
- Bolton S, Bon C. Pharmaceutical Statistics – Practical and Clinical Applications – Drugs and the Pharmaceutical Sciences. Vol 135. 4th ed. New York: Marcel Dekker Inc.; 2004. p. 215–64.
- De Muth TE. Basic Statistics and Pharmaceutical Statistical Applications. 2nd ed. Boca Raton: Chapman & Hall/CRS publication; 1999: p. 267–304.
- Huynh-Ba K. Handbook of Stability Testing in Pharmaceutical Development: Regulations, Methodologies and best practices. 17th ed. New York: Springer publications; 2009. p. 1–6.
- Velesco Pharmaceutical Services. What is a stability indicating method? [internet]. Available from: http://www.velescopharma.com/stability-indicating.asp
- Deshpande, A. A., Shah, N.H., Rhodes, C.T., Malick, W., Development of a novel controlled release system for gastric retention, Pharm. Res. 1997;14(6):815-9.
- Atyabi, F., Sharma, H.L., Mohammad, H., Fell, J. T., In- vivo evaluation of a novel gastroretentive formulation based on ion exchange resins, J. Control. Rel. 1996;42:105-13.
- Singh, B. N., Kim, K.H., Floating drug delivery systems an approach to oral controlled drug delivery via gastric retention, J Control Rel 2000;63:235-59.
- Shirwalkar, A. A., Kumar, S. M., Jacob, S., Recent developments in floating drug delivery systems for gastric retention of drugs, An overview. Indian drugs. 2006:43(9);697-704.
- Jain, S.K., Awasthi, A. M., Jain, N. K., Agrawal, G. P., Calcium silicate based microspheres of repaglinide for gastro-retentive floating drug delivery: preparation and in vitro characterization. J Control Release 2005;107:300Y309.
- Vyas, S. P., “Targeted and Controlled Drug Delivery Novel Carrier System”, I st Ed., CBS Publishers and Distributors, New Delhi, 2002 pp. 417-54.
How to Cite This Article
Vancouver
Karpe M, Kumbhar M, Tupe R, Bhamare G, Kadam V. Formulation, Optimization and Characterization of Gastro-rententive Troxipide Microspheres [Internet]. Int J Pharm Chem Anal. 2016 [cited 2025 Oct 28];3(3):133-142. Available from: https://doi.org/
APA
Karpe, M., Kumbhar, M., Tupe, R., Bhamare, G., Kadam, V. (2016). Formulation, Optimization and Characterization of Gastro-rententive Troxipide Microspheres. Int J Pharm Chem Anal, 3(3), 133-142. https://doi.org/
MLA
Karpe, Manisha, Kumbhar, Monika, Tupe, Ravindra, Bhamare, Gaurav, Kadam, Vilasrao. "Formulation, Optimization and Characterization of Gastro-rententive Troxipide Microspheres." Int J Pharm Chem Anal, vol. 3, no. 3, 2016, pp. 133-142. https://doi.org/
Chicago
Karpe, M., Kumbhar, M., Tupe, R., Bhamare, G., Kadam, V.. "Formulation, Optimization and Characterization of Gastro-rententive Troxipide Microspheres." Int J Pharm Chem Anal 3, no. 3 (2016): 133-142. https://doi.org/