Synthesis of some nuclear substitution derivatives of 4-acetyl pyridine

• Author Details:   
• Joohee Pradhan
• Anju Goyal

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Five nuclear substitution derivatives of 4- acetyl pyridine (2a to 6a) were prepared via N-oxidation followed by either nitration or arylation in the yield of 60-80%. Substitution at 2- position is promoted due to the electron withdrawing and meta- directing ability of acetyl group at 4- position making the pyridine N-oxide vulnerable to attack at C-2.

Keywords: 4- acetyl pyridine, N-oxidation, nitration, arylation, nuclear substitution.